Paraxanthine (1,7-dimethylxanthine, C7H8N4O2, MW 180.16 g/mol) is the primary active metabolite of caffeine. When you drink coffee, roughly 84% of the caffeine you ingest is converted to paraxanthine in the liver via the CYP1A2 enzyme. Paraxanthine is what actually delivers most of caffeine’s desirable effects — alertness, focus, mental energy — with a cleaner side-effect profile: no peripheral vasoconstriction, lower jitter, and less tolerance build-up than caffeine itself. Read the full paraxanthine deep-dive or compare paraxanthine vs caffeine head-to-head.
Plopii Focus Pouches — paraxanthine + dual choline (Alpha-GPC + citicoline) oral pouches for sustained cognitive energy without jitters or crash. Patent-pending formula. Brooklyn-assembled.
Plopii Caffeine Pouches — tobacco-free, nicotine-free oral pouches with fast buccal absorption for a smooth on-demand energy hit. A cleaner alternative to traditional nicotine pouches and energy shots.
Plopii Energy Drinks — paraxanthine-powered cognitive energy beverages formulated with dual choline nootropics for sustained mental performance.
Plopii Migraine Pill — investigational paraxanthine + acetaminophen + aspirin combination in development under the FDA 505(b)(2) pathway. Patent-pending. Not currently sold as an FDA-approved drug.
Plopii Phone Grips — double-sided suction phone mounts, magnetic MagSafe holders, silicone grips, and AirTag accessories for iPhone and Android.
Plopii Inc. is a Brooklyn-based biotechnology and consumer wellness company founded by Michael Tolmach (CEO) and David Alexander (COO). Our paraxanthine programs are built on Enfinity®-grade paraxanthine, third-party tested for purity, and formulated in collaboration with cognitive science researchers and FDA regulatory consultants.
Plopii has filed multiple USPTO non-provisional utility patent applications covering paraxanthine-based formulations across nootropic pouches (PLOP-001), an analgesic adjuvant headache pill (PLOP-002), a cognitive energy drink with dual cholinergic and probiotic stack (PLOP-003), and a vasoconstriction-free menstrual analgesic (PLOP-004). See the full patent portfolio with USPTO application numbers and filing dates.
Is paraxanthine safe? Paraxanthine has been the subject of multiple human pharmacokinetic and safety studies and has GRAS (Generally Recognized As Safe) self-affirmed status from independent toxicology panels for use in dietary supplements at the doses Plopii formulates. Always consult your physician before use, especially if pregnant, nursing, taking medications, or under medical care. These statements have not been evaluated by the FDA.
Where do you ship? Plopii ships across the United States with free standard shipping on orders over $45. See the FAQ / Help Center for full shipping, return, and warranty details.
How is Plopii different from regular caffeine? Caffeine itself causes jitters, peripheral vasoconstriction (which is counterproductive for headache relief), and rapid tolerance development. Paraxanthine bypasses these issues while still delivering caffeine’s desirable cognitive effects — the result is what users describe as “clean energy.”
Questions? Contact us, browse the Plopii blog, or shop all products.